Experimental trials with GMOs (other than plants)

GM adeno-associated viral vector derived from a naturally occurring AAV serotype (Rh74)

Non-replicating recombinant vector derived from adeno-associated virus serotype rh74

Recombinant live attenuated Yellow Fever Virus

GM adeno-associated virus AAV2

Non-replicating recombinant vector derived from adeno-associated virus serotype rh74

Non-replicating recombinant vector derived from adeno-associated virus AAV

Non-replicating recombinant adenovirus and orthopoxvirus

Live attenuated dengue quadrivalent vaccine

Non-replicating recombinant vector derived from adeno-associated virus AAV 5

Recombinant vesicular stomatitis virus

Recombinant viral vectors

Non-replicating recombinant adeno-associated virus serotype rh74

Recombinant vesicular stomatitis virus

Replication-incompetent adeno-associated virus, AAV9, lacking all AAV viral genes and encoding for the human Progranulin (GRN) gene

Live-attenuated vaccine

Recombinant non-replicating adeno-associated viral vector (AAV2/6) containing a codon-optimised version of the human Factor VIII gene

Recombinant GAd20 Gorilla adenovirus and Recombinant vaccinia virus Ankara (MVA) that contain the information to produce patient-specific cancer 'neoantigens' for treatment of skin and lung cancer

Recombinant AAV vector lacking viral genes and containing a gene encoding a shortened, but functional variant of the human dystrophin gene for treatment of Duchenne Muscular Dystrophy

Replicative oncolytic vaccinia virus with deletion of the viral thymidine kinase and ribonucleotide reductase genes, and addition of genes encoding for the human granulocyte-macrophage colony-stimulating factor cytokine and for a monoclonal antibody targeting the Cytotoxic T-Lymphocyte-Antigen 4

Recombinant replication-incompetent chimpanzee-derived adenovirus, and recombinant modified vaccinia virus Ankara vector (MVA), modified with Human Papillomavirus (HPV) surface antigens

Recombinant Vesicular Stomatitis Virus (rVSV) in which the gene coding for the VSV glycoprotein G has been deleted and replaced with the gene encoding the Zaire Ebola virus (ZEBOV) glycoprotein

Herpes simplex virus 1 (HSV-1) with gene expressing granulocyte-macrophage colony-stimulating factor (GH-CSF) and deletion of 2 HSV-1 genes

Recombinant Adeno-associated virus vector with gene cassette expressing human factor VIII

Recombinant chimpanzee-derived group C adenovirus expressing three proteins from the Respiratory Syncytial Virus (RSV)

Recombinant adeno associated viral vector containing a derivative of human coagulation factor IX cDNA

Recombinant adeno-associated virus serotype 2/9 (AAV2/9) containing the cDNA of the human SMN (Survival Motor Neuron) gene

Lactococcus lactis genetically modified to produce human interleukin-10 and proinsulin

Recombinant replication-defective simian (chimpanzee-derived) group C adenovirus, and recombinant modified vaccinia virus Ankara vector (MVA)

Lactococcus lactis expressing human Trefoil Factor 1 (hTFF1)

Novel live attenuated serotype 2 oral poliovirus vaccines (nOPV2) candidates

Herpes simplex virus 1 (HSV-1) with gene expressing granulocyte-macrophage colony-stimulating factor (GH-CSF) and deletion of 2 HSV-1 genes

Modified Vaccinia virus Ankara (MVA) with sequences coding for human mucine 1 (MUC1) antigen and interleukin-2 (IL2)

Herpes simplex virus 1 (HSV-1) with gene expressing granulocyte-macrophage colony-stimulating factor (GH-CSF) and deletion of 2 HSV-1 genes

Herpes simplex virus 1 (HSV-1) with gene expressing granulocyte-macrophage colony-stimulating factor (GH-CSF) and deletion of 2 HSV-1 genes

Herpes simplex virus 1 (HSV-1) with gene expressing granulocyte-macrophage colony-stimulating factor (GH-CSF) and deletion of 2 HSV-1 genes

Herpes simplex virus 1 (HSV-1) with gene expressing granulocyte-macrophage colony-stimulating factor (GH-CSF) and deletion of 2 HSV-1 genes

Recombinant Adeno-associated virus (rAAV) expressing SERCA2a enzym

Two recombinant non-pathogenic, non-replicative Lentiviruses for therapeuthic vaccination of HIV infected patients

Recombinant Actinobacillus pleuropneumoniae with modified virulence factors

Recombinant Vaccinia virus and Fowlpox virus expressing PSA and immunological costimulatory molecules

Recombinant Vaccinia virus expressing MUC1 antigen and hIL-2

Recombinant Vaccinia virus expressing hIL-2 and proteins of HPV virus

Recombinant bovine Parainfluenza virus with genes of human Parainfluenza virus and Respiratory syncitial virus

Recombinant Vaccinia virus with gene of Hepatitis B virus

Recombinant Lactococcus lactis expressing hIL-10

Recombinant feline herpes virus

Human adenovirus serotype 5 deleted in E1 and E3